To setup autoreply for mail follow the following steps:-

1)Login to Plesk control panel.

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2)Click on Subscriptions.

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3)Click on subscription name.

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4)Click onĀ  Mail tab.

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5)After click on mailbox name you will find the option of Auto-Reply, click on that.

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6)First select the check box for Switch on auto-reply then enter the subject and message for auto reply, At the end click on OK.

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7)Here you can see the Information:The settings of email address were saved.

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